Tetracaine Hydrochloride Potent local Anesthetic Pharmaceutical Tetracaine Raw Powder

Tetracaine Hydrochloride Potent local Anesthetic Pharmaceutical Tetracaine Raw Powder

Description:

Tetracaine HCl

Amethocaine hydrochloride

Anethaine

Butethanol

Curtacain

Decicain

Gingicain M

Menonasal

Pantocaine

Pontocaine hydrochloride

Tetracaine hydrochloride

Tonexol

potent local anesthetic

Chemical properties

CAS No.: 136-47-0
Molecular formula: C15H25ClN2O2 
Nolecular weight: 300.82 
EINECS: 205-248-5
Appearance: Fine white crystalline and odorless powder
Melting point: 145~150 degree

Mechanism of action

Tetracaine (INN, also known as amethocaine; Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

Uses

Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5‱ (per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

A systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties - however it did not find a statistically significant improvement in first attempt 

cannulations.

Applications:

Tetracaine is a kind of pharmaceutical raw materials used as a potent local anesthetic.

Tetracaine is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

Specifications:

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