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|Product Name:||Benzocaine||Appearance:||White Powder|
|CAS Number:||94-09-7||Application:||Local Anesthetic|
Benzocaine Pharmaceutical Raw Material Local Anesthetic Topical Pain Reliever
topical pain reliever
Benzocaine in cough drops
Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax.
Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform and ethyl ether.
The melting point of benzocaine is 88–90 °C, and the boiling point is about 310 °C. The density of benzocaine is 1.17 g/cm3.
Mechanism of action
Pain is caused by the stimulation of free nerve endings. When the nerve endings are stimulated, sodium enters the neuron, causing depolarization of the nerve and subsequent initiation of an action potential.
The action potential is propagated down the nerve toward the central nervous system, which interprets this as pain. Benzocaine acts to inhibit the voltage-dependent sodium channels (VDSCs) on the neuron membrane, stopping the propagation of the action potential.
Benzocaine is indicated to treat a variety of pain-related conditions. It may be used for:
Local anesthesia of oral and pharyngeal mucous membranes (sore throat, cold sores, mouth ulcers, toothache, sore gums, denture irritation)
Otic Pain (earache)
Surgical or procedural local anesthesia
Benzocaine can come in a variety of preparations including:
Lozenges (ex. Cepacol, Mycinettes)
Aerosol (ex. Topex)
Gel (ex. Orajel)
Paste (ex. Orabase)
Solution (ex. Allergen)
Benzocaine is used as a key ingredient in numerous pharmaceuticals:
Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear.
Some previous diet products such as Ayds.
Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer (in a continuous act) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted.
Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.
In Poland it is included, together with menthol and zinc oxide, in the liquid powder (not to be confused with the liquid face powder) used mainly after mosquito stings. Today's ready made Pudroderm was once used there as pharmaceutical compound.
Benzocaine is commonly found, particularly in Britain, as an impurity in street cocaine. Whilst giving a numbing effect similar to cocaine on users' gums it does not actually produce the effects of cocaine. But Also benzocaine can and has been mistaken for a false positive for cocaine.
Benzocaine is used as a topical pain reliever or in cough drops
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